Clinical utility of the GeneXpert assay for the diagnosis of Clostridium difficile infections
نویسندگان
چکیده
Background Since 2011 a rapid increase of cases with Clostridium difficile infection (CDI) was observed in the National Institute for Infectious Diseases (NIID), the largest tertiary level infectious diseases hospital in Romania. The need of a fast and accurate diagnosis of CDI and the low sensitivity of the available rapid immunoassays supported the introduction of a molecular assay as a part of the CDI diagnostic strategy. The present study aimed to evaluate the clinical utility of the GeneXpert Clostridium difficile (Cepheid, Sunnyvale, CA) assay in the diagnosis of CDI cases in NIID.
منابع مشابه
Detection of Clostridium difficile antigen and toxin in stool specimens: Comparison of the C. difficile quik chek complete enzyme immunoassay and GeneXpert C. difficile polymerase chain reaction assay
BACKGROUND/AIMS Accurate and rapid laboratory diagnosis of Clostridium difficile infections (CDI) remains a significant challenge. A two-step algorithm for detection of toxigenic C. difficile in stool based on initial screening for glutamate dehydrogenase assay followed by confirmation by toxin A+B detection using an enzyme immunoassay (EIA) or molecular assay has been proposed. We aimed to eva...
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